Histone methyltransferase KMT2C plays an oncogenic role in prostate cancer.

Jianpo LianChengdang XuXi ChenShengsong HuangDenglong Wu

Published in: Journal of cancer research and clinical oncology (2022)

Our study suggests that KMT2C plays an oncogenic role in PCa. One of the mechanisms may be the epigenetic regulation of CLDN8 and ITGAV by KMT2C to modulate tumor-signaling pathways. Therefore, KMT2C may serve as a potential therapeutic target for PCa patients.

Keyphrases

prostate cancer
end stage renal disease
newly diagnosed
signaling pathway
chronic kidney disease
transcription factor
dna methylation
prognostic factors
peritoneal dialysis
epithelial mesenchymal transition
gene expression
risk assessment
cell proliferation