Characteristics and Functions of Infection-enhancing Antibodies to the N-terminal Domain of SARS-CoV-2.
Ruth I ConnorMrunal SakharkarC Garrett RappazzoChengzi I KakuNicholas C CurtisSeungmin ShinWendy F Wieland-AlterJordan WentworthDaniel W MielcarzJoshua A WeinerMargaret E AckermanLaura M WalkerJiwon LeePeter F WrightPublished in: Pathogens & immunity (2024)
Functionally active NTD-specific mAbs arise frequently during natural infection and can last as major serum clonotypes during convalescence. These antibodies display functional attributes that include FcγR activation, and may be selected against by mutations in NTD associated with SARS-CoV-2 VOC.