PIEZO1 is essential for the survival and proliferation of acute myeloid leukemia cells.

Delphine LebonLouison ColletStefan DjordjevicCathy GomilaHakim Ouled-HaddouJessica PlatonYohann DemontJean-Pierre MarolleauAlexis CaulierLoïc Garçon

Published in: Cancer medicine (2024)

Altogether, our results reveal a new role for PIEZO1 mechanosensing in the survival and proliferation of leukemic blasts, which could pave the way for new therapeutic strategies to target AML cells.

Keyphrases

acute myeloid leukemia
induced apoptosis
signaling pathway
cell cycle arrest
endoplasmic reticulum stress
gene expression
dna methylation
free survival
genome wide