Ginsenoside Re protects methamphetamine-induced dopaminergic neurotoxicity in mice via upregulation of dynorphin-mediated κ-opioid receptor and downregulation of substance P-mediated neurokinin 1 receptor.

Duy-Khanh DangEun-Joo ShinDae-Joong KimHai-Quyen TranJi Hoon JeongChoon-Gon JangSeung-Yeol NahJung Hwan JeongJae Kyung ByunSung Kwon KoGuoying BingJau-Shyong HongHyoung-Chun Kim

Published in: Journal of neuroinflammation (2018)

Our results suggest that GRe protects MA-induced dopaminergic neurotoxicity via upregulatgion of dynorphin-mediated κ-opioid receptor and downregulation of substance P-mediated NK1 R.

Keyphrases

cell proliferation
chronic pain
signaling pathway
pain management
high glucose
diabetic rats
type diabetes
metabolic syndrome
adipose tissue
binding protein
skeletal muscle
high fat diet induced
insulin resistance