GCSB-5 regulates inflammatory arthritis and pain by modulating the mitogen-activated protein kinase signaling pathway in a murine model of rheumatoid arthritis.
Jihye BangGyeong Hwa KimSoo-Young ParkHae Ra JungSang-Hyon KimJi-Min KimPublished in: Archives of rheumatology (2022)
GCSB-5 decreased inflammatory arthritis and pain in a murine model of RA. The results present evidence that GCSB-5 may be beneficial for relieving pain as well as decreasing inflammation in autoimmune arthritis, such as RA.
Keyphrases
- rheumatoid arthritis
- chronic pain
- disease activity
- signaling pathway
- pain management
- oxidative stress
- neuropathic pain
- interstitial lung disease
- ankylosing spondylitis
- multiple sclerosis
- pi k akt
- epithelial mesenchymal transition
- induced apoptosis
- spinal cord injury
- systemic sclerosis
- drug induced
- idiopathic pulmonary fibrosis