Amotosalen and ultraviolet A light efficiently inactivate MERS-coronavirus in human platelet concentrates.

Anwar M HashemA M HassanA M TolahM A AlsaadiQ AbunadaG A DamanhouriS A El-KafrawyM Picard-MaureauE I AzharS I Hindawi

Published in: Transfusion medicine (Oxford, England) (2019)

Amotosalen and UVA light treatment of MERS-CoV-spiked platelet concentrates efficiently and completely inactivated MERS-CoV infectivity (>4 logs), suggesting that such treatment could minimise the risk of transfusion-related MERS-CoV transmission.

Keyphrases

respiratory syndrome coronavirus
sars cov
coronavirus disease
endothelial cells
acute kidney injury
sickle cell disease
replacement therapy