Pyridoxine or pyridoxal-5-phosphate treatment for seizures in glycosylphosphatidylinositol deficiency: A cohort study.
Carolina AlvarezAngel Aledo-SerranoAntonio Gil-NagelChristian M KorffAshley ThomasChristian Malte BoßelmannYvonne WeberElena GardellaAllan M LundMonique G M de Sain-van der VeldenRikke S MøllerPublished in: Developmental medicine and child neurology (2022)
is a potential disease-specific treatment; however, efficacy and safety are ill-defined. Pyridoxine may reduce seizure frequency or burden in inherited GPI deficiency. Pyridoxine and P5P could prove to be a useful treatment in some individuals with inherited GPI deficiency and epilepsy.