Convalescent plasma donors show enhanced cross-reactive neutralizing antibody response to antigenic variants of SARS-CoV-2 following immunization.

Heli HarvalaDung NguyenPeter SimmondsAbigail A LamikanraHoi Pat TsangAshley OtterPiet MaesMhairi WebsterAdam ClarksonFotini KaloyirouValerie HopkinsStephen M LaidlawMiles CarrollAna MoraAlexandra GriffithsSheila MacLennanLise EstcourtDavid J Roberts

Published in: Transfusion (2022)

Vaccination of previously infected CP donors induced high levels of broadly neutralizing antibodies against circulating antigenic variants of SARS-CoV-2. High titer donations could be reliably identified by automated quantitative anti-spike antibody assay, enabling large-scale preselection of high-titer convalescent plasma.

Keyphrases

sars cov
respiratory syndrome coronavirus
high throughput
copy number
dengue virus
machine learning
deep learning
kidney transplantation
diabetic rats
high glucose
oxidative stress
drug induced
mass spectrometry
endothelial cells