Dynamic blood oxygen indices in mechanically ventilated COVID-19 patients with acute hypoxic respiratory failure: A cohort study.
Luke BracegirdleAlexander I R JacksonRyan BeechamMaria BurovaElsie HunterLaura G HamiltonDarshni PandyaClare MordenMichael P W GrocottAndrew F CumpsteyAhilanandan Dushianthannull nullPublished in: PloS one (2022)
As a novel cause of acute hypoxic respiratory failure, COVID-19 offers a unique opportunity to study a homogenous cohort of patients with hypoxaemia. In mechanically ventilated adult COVID-19 patients, blood oxygen indices are abnormal with substantial divergence in PaO2/FiO2 ratio and oxygen extraction ratio between survivors and non-survivors. Despite having higher CaO2 values, non-survivors appear to extract less oxygen implying impaired oxygen utilisation. Further exploratory studies are warranted to evaluate and improve oxygen extraction which may help to improve outcomes in severe hypoxaemic mechanically ventilated COVID-19 patients.
Keyphrases
- respiratory failure
- extracorporeal membrane oxygenation
- sars cov
- acute respiratory distress syndrome
- mechanical ventilation
- intensive care unit
- coronavirus disease
- young adults
- oxidative stress
- type diabetes
- early onset
- adipose tissue
- metabolic syndrome
- hepatitis b virus
- respiratory syndrome coronavirus
- insulin resistance
- weight loss