Improvement of sensory neuron growth and survival via negatively regulating PTEN by miR-21-5p-contained small extracellular vesicles from skin precursor-derived Schwann cells.

Meng CongMi ShenXia WuYan LiLiting WangQianru HeHai-Yan ShiFei Ding

Published in: Stem cell research & therapy (2021)

Sum up, SKP-SC-EVs could improve neurite outgrowth of DRG sensory neurons in physiological and pathological condition. Moreover, the in vitro therapeutic potential of SKP-SC-EVs on the survival and restoration of OGD-injured sensory neurons was evidenced to be associated with miR-21-5p contained in the small EVs and miR-21-5p/PTEN/PI3K/Akt axis.

Keyphrases

pi k akt
cell cycle arrest
signaling pathway
cell proliferation
induced apoptosis
spinal cord
free survival
cell death
spinal cord injury
wound healing