Chemokine ligand 28 (CCL28) negatively regulates trabecular bone mass by suppressing osteoblast and osteoclast activities.

Rina IwamotoTakumi TakahashiKazuto YoshimiYuji ImaiTsuyoshi KoideMiroku HaraTadashi NinomiyaHiroaki NakamuraKazutoshi SayamaAkira Yukita

Published in: Journal of bone and mineral metabolism (2021)

In summary, this study indicated that CCL28 is one of the negative regulators of bone mass by suppressing osteoblast and osteoclast activities. These results provide important insights into bone immunology and the selection of new osteoporosis treatments.

Keyphrases

bone mineral density
bone loss
bone regeneration
postmenopausal women
body composition
soft tissue
liver injury
liver fibrosis
drug induced