A Study on the Immunohistochemical Expressions of Leptin and Leptin Receptor in Clear Cell Renal Cell Carcinoma.
Komathi PerumalKein Seong MunNing Yi YapAzad Hassan Abdul RazackGlenda Carolyn GobeTeng Aik OngShanggar KuppusamyRetnagowri RajandramPublished in: BioMed research international (2020)
In this present study, it was revealed that leptin and leptin receptor were not associated with tumour characteristics and progression of ccRCC patients. Interestingly, nuclear expression of leptin was significantly associated with overall survival. However, the significance of these proteins as biomarkers in other RCC histotypes is still unclear.