Levels of angiotensin-converting enzyme 1 and 2 in serum and urine of children with Sickle Cell Disease.

Ho Chi Hsien Dulce Elena Casarini João Tomas de Abreu Carvalhaes Fernanda Aparecida Ronchi Lilian Caroline Gonçalves de Oliveira Josefina Aparecida Pellegrini Braga

Published in: Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia (2021)

Our data revealed a high urinary ACE 1 activity, different than plasmatic level, in SCD patients suggesting a dissociation between the intrarenal and systemic RAAS. The increase of urinary ACE 1 activity in SCD patients suggests higher levels of Ang II with a predominance of classical RAAS axis, that can induce kidney damage.

Keyphrases

angiotensin converting enzyme
angiotensin ii
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
peritoneal dialysis
machine learning
oxidative stress
artificial intelligence
big data
deep learning