The Contribution of Germline Pathogenic Variants in Breast Cancer Genes to Contralateral Breast Cancer Risk in BRCA1/BRCA2/PALB2 -Negative Women.

Alexey LarionovEleanor FewingsJames RedmanMae GoldgrabenGraeme ClarkJohn BoicePatrick ConcannonJonine BernsteinDavid V Continull The Wecare Study Collaborative GroupMarc Tischkowitz

Published in: Cancers (2023)

-negative women, the aggregated burden of PGVs in breast cancer risk genes was associated with the increased risk of CBC and was inversely proportional to the age at onset.

Keyphrases

breast cancer risk
genome wide
bioinformatics analysis
genome wide identification
copy number
gene expression
type diabetes
dna repair
dna methylation
risk factors
pregnant women
adipose tissue
skeletal muscle
transcription factor