Selective recognition of A/T-rich DNA 3-way junctions with a three-fold symmetric tripeptide.
Jacobo Gómez-GonzálezLaura Martínez-CastroJuan TolosaAna Alcalde-OrdóñezSoraya Learte-AymamíJosé Luis MascareñasJoaquín C García MartínezJacobo GómezJean-Didier MaréchalMiguel Vázquez LópezM Eugenio VázquezPublished in: Chemical communications (Cambridge, England) (2022)
Non-canonical DNA structures, particularly 3-Way Junctions (3WJs) that are transiently formed during DNA replication, have recently emerged as promising chemotherapeutic targets. Here, we describe a new approach to target 3WJs that relies on the cooperative and sequence-selective recognition of A/T-rich duplex DNA branches by three AT-Hook peptides attached to a three-fold symmetric and fluorogenic 1,3,5-tristyrylbenzene core.