Association of the CYP17 and CYP19 gene polymorphisms in women with polycystic ovary syndrome from Punjab, Pakistan.

Nasira Munawar LoneSana BabarSikandar SultanSaira MalikKiran NazeerSaba Riaz

Published in: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology (2020)

This is the first study on PCOS genotypes from Pakistan and results suggest that CYP 17 5'-UTR MspA1 (rs743572) (genotype TC) and CYP 19 gene (rs2414096) (genotype GA) polymorphisms are significantly associated with susceptibility to PCOS in Pakistani women having the traits of infertility and family history of hypertension.

Keyphrases

polycystic ovary syndrome
insulin resistance
genome wide
blood pressure
pet ct
metabolic syndrome
pregnant women
dna methylation
type diabetes
copy number
gene expression
transcription factor
cervical cancer screening
skeletal muscle
genome wide identification
arterial hypertension