Device-Aided Therapies in Parkinson's Disease-Results from the German Care4PD Study.
Odette FründtAnne-Marie HanffAnnika MöhlTobias MaiChristiane KirchnerAli AmouzandehCarsten BuhmannRejko KrügerMartin SüdmeyerPublished in: Brain sciences (2023)
Data on the use of device-aided therapies (DATs) in people with Parkinson's disease (PwP) are scarce. Analyzing data from the Care4PD patient survey, we (1) evaluated application frequency and type of DAT in a larger, nationwide, cross-sectoral PwP sample in Germany; (2) analyzed the frequency of symptoms indicative for advanced PD (aPD) and need for DAT amongst the remaining patients and (3) compared the most bothersome symptoms and need for professional long-term care (LTC) of patients with and without suspected aPD. Data from 1269 PwP were analyzed. In total, 153 PwP (12%) received DAT, mainly deep brain stimulation (DBS). Of the remaining 1116 PwP without DAT, >50% fulfilled at least one aPD criterion. Akinesia/rigidity and autonomic problems were most bothersome for PwP with and without suspected aPD, with more tremor in the non-aPD and more motor fluctuations and falls in the aPD group. To recapitulate, the German DAT application rate is rather low, although a large proportion of PwP fulfills aPD criteria indicating a need for intensified treatment strategies. Many reported bothersome symptoms could be overcome with DAT with benefits even for LTC patients. Thus, precise and early identification of aPD symptoms (and therapy-resistant tremor) should be implemented in future DAT preselection tools and educational trainings.
Keyphrases
- deep brain stimulation
- end stage renal disease
- parkinson disease
- ejection fraction
- palliative care
- healthcare
- long term care
- newly diagnosed
- chronic kidney disease
- obsessive compulsive disorder
- peritoneal dialysis
- electronic health record
- sleep quality
- prognostic factors
- mental health
- bone marrow
- pulmonary embolism
- big data
- machine learning
- mesenchymal stem cells
- case report
- chronic pain
- patient reported outcomes
- heart rate
- physical activity