BRCA1, BRCA2, and TP53 germline and somatic variants and clinicopathological characteristics of Brazilian patients with epithelial ovarian cancer.
Caroline Stahnke RichauNicole de Miranda SchererBruna Palma MattaElvismary Molina de ArmasFábio Carvalho de Barros MoreiraAnke BergmannClaudia Bessa Pereira ChavesMariana BoroniAnna Claudia Evangelista Dos SantosMiguel Angelo Martins MoreiraPublished in: Cancer medicine (2024)
Frequency of pathogenic or likely pathogenic germline variants in BRCA1 and BRCA2 (12.5%) was lower in comparison with other studies. TP53 was the most altered gene in tumors, with 62.5% presenting likely non-functional or non-functional somatic variants, while eight 14.2% presented likely non-functional or non-functional somatic variants in BRCA1 or BRCA2.