A field guide to Aurora kinase inhibitors: an oocyte perspective.

Cecilia S BlenginiGyu Ik JungMansour AboelenainKaren Schindler

Published in: Reproduction (Cambridge, England) (2022)

Several small molecule inhibitors exist for targeting Aurora kinase proteins in somatic cells. From this point of view, we evaluate the specificity of these inhibitors in mouse oocytes, and we demonstrate that MLN 8237 and AZD 1152 are specific for Aurora kinase A and Aurora kinase C, respectively, only when used at low concentrations.

Keyphrases

small molecule
protein kinase
tyrosine kinase
cancer therapy
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