Lysyl oxidase regulates epithelial differentiation and barrier integrity in eosinophilic esophagitis.

Masaru Sasaki Takeo Hara Joshua X Wang Yusen ZhouKanak V KennedyNicole N UmeweniMaiya A AlstonZachary C SpergelRitsu NakagawaEmily A McmillanKelly A WhelanTatiana A Karakasheva Kathryn E Hamilton Melanie A Ruffner Amanda B Muir

Published in: bioRxiv : the preprint server for biology (2023)

Our data support a model whereby LOX exhibits non-canonical roles as a signaling molecule important for epithelial homeostasis in the setting of inflammation via activation of BMP pathway in esophagus. The LOX/BMP axis may be integral in esophageal epithelial differentiation and a promising target for future therapies.

Keyphrases

mesenchymal stem cells
oxidative stress
bone regeneration
machine learning
current status
bone marrow
artificial intelligence