Bag-1 stimulates Bad phosphorylation through activation of Akt and Raf kinases to mediate cell survival in breast cancer.
Tugba KizilbogaEmine Arzu BaskaleJale YildizIzzet Mehmet AkcayEbru ZemheriNisan Denizce CanCan OzdenSalih DemirFikret EzberciGizem Dinler DoganayPublished in: BMC cancer (2019)
Overall, Bad inhibition by Bag-1 through activation of Raf and Akt kinases is an effective survival and growth strategy exploited by breast cancer cells. Therefore, targeting the molecular interactions between Bag-1 and these kinases might prove an effective anticancer therapy.