Involvement of TOB1 on autophagy in gastric cancer AGS cells via decreasing the activation of AKT/mTOR signaling pathway.

Dong WangYunlong LiShuning SuiMengdi CaiKexian DongPing WangXiao LiangSongbin FuJingcui Yu

Published in: PeerJ (2022)

Our results provide novel insight that TOB1 might suppress gastric cancer by inducing autophagy, possibly through decreasing phosphorylation and the subsequent activation of the AKT/mTOR signaling pathway.

Keyphrases

signaling pathway
induced apoptosis
pi k akt
cell cycle arrest
epithelial mesenchymal transition
cell proliferation
cell death