Inhibition of mast cells: a novel mechanism by which nintedanib may elicit anti-fibrotic effects.

Catherine Overed-Sayer Elena MirandaRebecca DunmoreElena Liarte MarinLorea BelokiDoris RasslHelen ParfreyAlan CarruthersAmina ChahboubSofia KochGülin Güler-GaneMichael KuzioraArthur Lewis Lynne Anne MurrayRichard MayDeborah Clarke

Published in: Thorax (2020)

Nintedanib inhibits MC survival and activation and thus provides a novel additional mechanism by which this drug may exert anti-fibrotic effects in patients with IPF.

Keyphrases

idiopathic pulmonary fibrosis
interstitial lung disease
systemic sclerosis
emergency department