GluN2B on adult-born granule cells modulates (R,S)-ketamine's rapid-acting effects in mice.

Nicholas E BulthuisJosephine C McGowanLiliana R LadnerChristina T LaGammaSean C LimClaire X ShubeckRebecca A BrachmanEzra SydnorIna P PavlovaDong-Oh SeoMichael R DrewChristine A Denny

Published in: The international journal of neuropsychopharmacology (2024)

In line with previous studies, these results suggest that 6-week-old adult-born hippocampal neurons expressing GluN2B partially modulate (R,S)-ketamine's rapid-acting effects. Future work targeting these 6-week-old adult-born neurons may prove beneficial for increasing the efficacy of (R,S)-ketamine.

Keyphrases

gestational age
low birth weight
pain management
spinal cord
induced apoptosis
childhood cancer
type diabetes
clinical trial
oxidative stress
current status
cancer therapy
preterm birth
high fat diet induced
brain injury
signaling pathway