A novel small molecule inhibitor of p32 mitochondrial protein overexpressed in glioma.
Venkata YenugondaNatsuko NomuraValentina KouznetsovaIgor TsigelnyValentina FogalElmar NurmemmedovSantosh KesariIvan BabićPublished in: Journal of translational medicine (2017)
This study demonstrates a novel screening strategy to identify potential inhibitors of mitochondrial p32 protein overexpressed in glioma. High throughput screening employing this strategy has potential to identify highly selective, potent, brain-penetrant small molecules amenable for further drug development.