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A novel small molecule inhibitor of p32 mitochondrial protein overexpressed in glioma.

Venkata YenugondaNatsuko NomuraValentina KouznetsovaIgor TsigelnyValentina FogalElmar NurmemmedovSantosh KesariIvan Babić
Published in: Journal of translational medicine (2017)
This study demonstrates a novel screening strategy to identify potential inhibitors of mitochondrial p32 protein overexpressed in glioma. High throughput screening employing this strategy has potential to identify highly selective, potent, brain-penetrant small molecules amenable for further drug development.
Keyphrases
  • small molecule
  • protein protein
  • oxidative stress
  • amino acid
  • binding protein
  • white matter
  • cerebral ischemia
  • subarachnoid hemorrhage