Dysregulation of extracellular matrix and Lysyl Oxidase in Ehlers-Danlos syndrome type IV skin fibroblasts.

Reece FoehrKeith AndersonOwen DombrowskiAnna FoehrErik D Foehr

Published in: Orphanet journal of rare diseases (2024)

Together, these findings suggest dysregulated ECM deposition and processing, reminiscent of a state of fibrosis. Therapeutics that target the dysregulated ECM proteins or help replace damaged tissue may improve clinical outcomes.

Keyphrases

extracellular matrix
small molecule
soft tissue
case report
wound healing