In Situ Sprayed Starvation/chemodynamic Therapeutic Gel for Post-surgical Treatment of IDH1 Glioma.
Chunying LiYilin WanYifan ZhangLian-Hua FuNicholas Thomas BlumRun CuiBoda WuRui ZhengJing LinZhiming LiPeng HuangPublished in: Advanced materials (Deerfield Beach, Fla.) (2021)
Complete resection of IDH1 (R132H) glioma is infeasible and the classic post-surgical chemo/radiotherapy suffers from high recurrence and low survival rate. IDH1 (R132H) cells are sensitive to low concentration of glucose and high concentration of reactive oxygen species (ROS) due to inherent metabolism reprograming. Hence, a starvation/chemodynamic therapeutic gel was developed to combat residual IDH1 (R132H) tumor cells after surgery. Briefly, glucose oxidase (GOx) is mineralized with manganese-doped calcium phosphate to form GOx@MnCaP nanoparticles, which were encapsulated into the fibrin gel (GOx@MnCaP@fibrin). After spraying gel in the surgical cavity, GOx catalyzed the oxidation of glucose in residual IDH1 (R132H) cells and produced H2 O2 . The generated H2 O2 was further converted into highly lethal hydroxyl radicals (•OH) by Mn2+ mediated Fenton-like reaction to further kill the residual IDH1 (R132H) cells. The as-prepared starvation/chemodynamic therapeutic gel showed much higher therapeutic efficacy towards IDH1 (R132H) cells than IDH1 (WT) cells, and achieved long-term survival. This article is protected by copyright. All rights reserved.
Keyphrases
- induced apoptosis
- low grade
- cell cycle arrest
- reactive oxygen species
- cell death
- endoplasmic reticulum stress
- early stage
- adipose tissue
- oxidative stress
- blood pressure
- nitric oxide
- metabolic syndrome
- squamous cell carcinoma
- drug delivery
- signaling pathway
- high grade
- type diabetes
- dna damage
- insulin resistance
- weight loss
- cell proliferation
- photodynamic therapy
- quantum dots
- cancer therapy
- highly efficient