Retinal genes are differentially expressed in areas of primary versus secondary degeneration following partial optic nerve injury.
Wissam ChihaChrisna J LeVaillantCarole A BartlettAlex W HewittPhillip E MeltonMelinda FitzgeraldAlan R HarveyPublished in: PloS one (2018)
There was an acute and complex primary injury response in dorsal retina indicative of a dynamic interaction between neuroprotective and neurodegenerative events; ventral retina vulnerable to secondary degeneration showed a delayed injury response. Both primary and secondary injury resulted in the upregulation of numerous genes linked to RGC death, but differences in the nature of these changes strongly suggest that death occurred via different molecular mechanisms.
Keyphrases
- optic nerve
- optical coherence tomography
- diabetic retinopathy
- spinal cord
- genome wide
- cell proliferation
- liver failure
- signaling pathway
- spinal cord injury
- gene expression
- intensive care unit
- hepatitis b virus
- blood brain barrier
- cerebral ischemia
- genome wide identification
- neuropathic pain
- dna methylation
- extracorporeal membrane oxygenation
- genome wide analysis