Exploring the relationship between metabolism and immune microenvironment in osteosarcoma based on metabolic pathways.

Changwu WuJun TanHong ShenChao DengChristian KleberGeorg OsterhoffNikolas Schopow

Published in: Journal of biomedical science (2024)

The metabolism of vitamins and cofactors is an important prognostic regulator of TIME in osteosarcoma, MRG-related gene clusters can well reflect changes in osteosarcoma TIME and predict chemotherapy and immunotherapy response. The metabolism-related risk model may serve as a useful prognostic predictor. ST3GAL4 plays a critical role in the progression, glycolysis, and TIME of osteosarcoma cells.

Keyphrases

induced apoptosis
stem cells
cell cycle arrest
genome wide
oxidative stress
radiation therapy
signaling pathway
locally advanced
pi k akt