Ischemic preconditioning protects the heart against ischemia-reperfusion injury in chronic kidney disease in both males and females.

Márta Sárközy Fanni Magdolna Márványkövi Gergő Szűcs Zsuzsanna Z A Kovács Márton Richárd Szabó Renáta Gáspár Andrea Siska Bence Kővári Gábor Cserni Imre Földesi Tamás Csont

Published in: Biology of sex differences (2021)

The infarct size-limiting effect of IPRE was preserved in both sexes in CKD despite the more severe uremic cardiomyopathy in male CKD rats. Further research is needed to identify crucial molecular mechanisms in the cardioprotective effect of IPRE in CKD.

Keyphrases

ischemia reperfusion injury
chronic kidney disease
heart failure
oxidative stress
cerebral ischemia
early onset
acute myocardial infarction
brain injury
subarachnoid hemorrhage
percutaneous coronary intervention