Increased antitumor efficacy of PD-1-deficient melanoma-specific human lymphocytes.
Lucine MarotteSylvain SimonVirginie VignardEmilie DupreMalika GantierJonathan CruardJean-Baptiste AlbergeMelanie HussongCecile DeleineJean-Marie HeslanJonathan ShafferTiffany BeauvaisJoelle GaschetEmmanuel ScotetDelphine FradinAnne JarryTuan NguyenNathalie LabarrièrePublished in: Journal for immunotherapy of cancer (2021)
The use of such lymphocytes for adoptive cell transfer purposes, associated with other approaches modulating the tumor microenvironment, would be a promising alternative to improve immunotherapy efficacy in solid tumors.