Tranexamic acid is associated with selective increase in inflammatory markers following total knee arthroplasty (TKA): a pilot study.

Andrea L GrantHayley L LetsonJodie L MorrisPeter McEwenKaushik HazratwalaMatthew WilkinsonGeoffrey P Dobson

Published in: Journal of orthopaedic surgery and research (2018)

TXA was associated with increased systemic inflammation during surgery compared to non-TXA patients, with further amplification on postoperative days 1 and 2. On the basis of little or no change in viscoelastic clot strength, fibrinogen or clot lysis, there appeared to be no clinical justification for TXA in our group of patients. Larger prospective, randomized trials are required to investigate a possible proinflammatory effect in TKA patients.

Keyphrases

total knee arthroplasty
end stage renal disease
ejection fraction
newly diagnosed
prognostic factors
peritoneal dialysis
total hip
patient reported outcomes
coronary artery bypass
acute coronary syndrome