Systematic review with meta-analysis: efficacy and safety of treatments for opioid-induced constipation.

Priya VijayvargiyaMichael CamilleriPooja VijayvargiyaPatricia ErwinM Hassan Murad

Published in: Alimentary pharmacology & therapeutics (2020)

Therapeutic response in opioid-induced constipation is best achieved with the PAMORAs, methylnaltrexone, naloxegol and naldemidine, which are associated with low risk of serious adverse events.

Keyphrases

high glucose
chronic pain
diabetic rats
pain management
irritable bowel syndrome
oxidative stress
endothelial cells