Dapiglutide, a novel dual GLP-1 and GLP-2 receptor agonist, attenuates intestinal insufficiency in a murine model of short bowel.
Johannes ReinerPeggy BerlinJascha HeldJohanna ThieryJolanta SkarbalieneJonathan GriffinWayne RussellPer-Olof ErikssonMark Berner-HansenLuise EhlersBrigitte VollmarRobert JasterMaria WitteGeorg LamprechtPublished in: JPEN. Journal of parenteral and enteral nutrition (2021)
Dapiglutide possesses specific and potent GLP-1R and GLP-2R agonist effects in rodents. In the murine SB model, combined unimolecular GLP-1R and GLP-2R stimulation with dapiglutide potently attenuates intestinal insufficiency and potentially also IF.
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