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Mesenchymal stromal cells and their secretory products reduce the inflammatory crosstalk between islets and endothelial cells.

Rebecca Dewhurst-TriggJessica HopkinsonSarah J RichardsonPeter M JonesChloe L Rackham
Published in: Endocrine (2024)
MSC-derived secretory factors, including ANXA1, may be used in islet transplantation protocols to target donor islet and host EC inflammation at the intraportal niche.
Keyphrases
  • endothelial cells
  • oxidative stress
  • bone marrow
  • high glucose
  • cell therapy
  • stem cells
  • vascular endothelial growth factor