Cell-cell contact-dependent secretion of large-extracellular vesicles from EFNB high cancer cells accelerates peritoneal dissemination.

Kaito HayashiKurara TakaganeGo ItohSei KuriyamaSouichi KoyotaKenji MeguroYiwei LingTatsuya AbéRiuko OhashiMasakazu YashiroMasaru MizunoMasamitsu Tanaka

Published in: British journal of cancer (2024)

cancer cells scattered LEVs when they attached to PMCs, which augmented the local reactions of PMC and MΦ (MMT and lymphangiogenesis) and exaggerated peritoneal dissemination.

Keyphrases

single cell
cell therapy
stem cells
mesenchymal stem cells