Transcriptomics Analysis of the Tumor-Inhibitory Pathways of 6-Thioguanine in MCF-7 Cells via Silencing DNMT1 Activity.

Hao LiXinglan AnDaoyu ZhangQi LiNan ZhangHao Yu Ziyi Li

Published in: OncoTargets and therapy (2020)

Overall, our results suggest that 6-TG may induce FAS-mediated exogenous apoptosis and p21-dependent G2/M arrest by inhibiting the activity of DNMT1 in MCF-7 breast cancer cells.

Keyphrases

breast cancer cells
cell cycle arrest
dna methylation
induced apoptosis
endoplasmic reticulum stress
cell death
oxidative stress
signaling pathway
pi k akt
single cell
gene expression
cell cycle
cell proliferation