The evolution of transcriptional repressors in the Notch signaling pathway: a computational analysis.

Published in: Hereditas (2019)

Notch repressors appear to be specific to either chordates or arthropods. Orthologues of experimentally validated repressors were not found outside the phylogenetic group they have been originally identified. However, the data provide a hypothesis on the evolution of mammalian KyoT2 from Prickle like ancestors. The finding of a potential CSL interacting domain in Prickle homologues points to a novel, very ancestral CSL interactor present in the entire animal kingdom.

Keyphrases

signaling pathway
cell proliferation
gene expression
pi k akt
electronic health record
transcription factor
epithelial mesenchymal transition
machine learning
risk assessment
induced apoptosis
oxidative stress
protein kinase
deep learning
endoplasmic reticulum stress