Idiopathic male infertility is strongly associated with aberrant DNA methylation of imprinted loci in sperm: a case-control study.

Qiuqin TangFeng PanJing YangZiqiang FuYiwen LuXian WuXiumei HanMinjian ChenChuncheng LuYankai XiaXinru WangWei Wu

Published in: Clinical epigenetics (2018)

We conclude that abnormalities of DMR within imprinted genes may be associated with idiopathic male infertility. Disruption in methylation pattern of the three imprinted genes does not occur in high-risk genotypes of DNMTs.

Keyphrases

genome wide
dna methylation
solid phase extraction
copy number
gene expression
polycystic ovary syndrome
genome wide identification
bioinformatics analysis
metabolic syndrome
insulin resistance
genome wide analysis
adipose tissue