SIRT1 negatively regulates invasive and angiogenic activities of the extravillous trophoblast.

Ki Mo LeeHee Won SeoMyoung-Seung KwonAe-Ra HanSung Ki Lee

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2019)

Our results suggest that SIRT1 may be associated with placental development by controlling EVT invasion and spiral artery remodeling via modulation of EMT, MMP-2, MMP-9, Akt/p38MAPK signaling, and Fas/FasL.

Keyphrases

cell migration
oxidative stress
ischemia reperfusion injury
epithelial mesenchymal transition
signaling pathway
cell proliferation