Persistence of High Percentage of Peripheral Activated CD8+ T Cells Predict Cytologic HPV-Related Dysplasia in cART-Treated, HIV-Positive Subjects.
Debora MondatoreFrancesca BaiMatteo AugelloMarco GiovenzanaAndrea Pisani CerettiValeria BonoEnrico OpocherAntonella d'Arminio MonforteGiulia Carla MarchettiCamilla TincatiPublished in: Open forum infectious diseases (2022)
HPV infection is the major driver of dysplasia in the setting of HIV infection. In this study, CD8+ CD38+ T cells were an independent predictor of dysplasia in cART-treated subjects, while CD4:CD8 T-cell ratio was not. In the setting of HIV-HPV coinfection, CD4:CD8 T-cell ratio may not fully capture the alterations of HPV-specific immunity.