Alzheimer's disease cerebrospinal fluid biomarkers differentiate patients with Creutzfeldt-Jakob disease and autoimmune encephalitis.
Bryce K ChangGregory S DayJonathan Graff-RadfordAndrew McKeonEoin P FlanaganAlicia Algeciras-SchimnichMichelle M MielkeAivi NguyenDavid T JonesMichel ToledanoWalter K KremersDavid S KnopmanRonald C PetersenWentao LiPublished in: European journal of neurology (2022)
Total-tau was greater in CJD than AE. Given that amyloid-β<sub>42</sub> and phosphorylated<sub>181</sub> tau were comparable, the ratio differences were probably driven by elevated total-tau in CJD. This study supports the role for AD biomarker testing in patients with rapidly progressive dementia.