Role of Lysophospholipid Metabolism in Chronic Myelogenous Leukemia Stem Cells.
Kazuhito NakaPublished in: Cancers (2021)
It is well known that mature chronic myelogenous leukemia (CML) cells proliferate in response to oncogenic BCR-ABL1-dependent signaling, but how CML stem cells are able to survive in an oncogene-independent manner and cause disease relapse has long been elusive. Here, I put into the context of the broader literature our recent finding that lysophospholipid metabolism is essential for the maintenance of CML stem cells. I describe the fundamentals of lysophospholipid metabolism and discuss how one of its key enzymes, Glycerophosphodiester Phosphodiesterase Domain Containing 3 (Gdpd3), is responsible for maintaining the unique characteristics of CML stem cells. I also explore how this knowledge may be exploited to devise novel therapies for CML patients.
Keyphrases
- stem cells
- chronic myeloid leukemia
- end stage renal disease
- acute myeloid leukemia
- cell therapy
- ejection fraction
- induced apoptosis
- systematic review
- tyrosine kinase
- chronic kidney disease
- acute lymphoblastic leukemia
- prognostic factors
- healthcare
- newly diagnosed
- peritoneal dialysis
- oxidative stress
- patient reported outcomes
- transcription factor
- cell cycle arrest
- mesenchymal stem cells
- pi k akt
- free survival