Levels of inflammatory markers are differentially expressed in sickle cell anemia and sickle cell trait.
Ingrid Cristiane Pereira GomesLucas Sousa MagalhãesLays Gisele Santos BomfimPriscila Lima Dos SantosRoberto Jerônimo Dos Santos SilvaMaria Carollyne Passos CruzLindemberg Costa de AlbuquerqueVictoria Haydée Deusdedith NevesPaula Gabriella Pereira Rosa de OliveiraAlessandro Freire CarvalhoLucas Oliveira SilvaMatheus Todt AragãoTatiana Rodrigues de MouraRosana CipolottiPublished in: EJHaem (2023)
Although sickle cell anemia (SCA) is related to inflammation, the profile of inflammatory markers in sickle cell trait (SCT) is poorly studied. This is a cross-sectional study of inflammatory biomarkers carried out involving adults with SCA in steady state, SCT and controls. The SCA group had higher levels of lactato dehydrogenase, IL-1β, IL-6, IL-10, and tumor necrosis factor alpha than the others, while the SCT group had similar levels to control group. In addition, SCA group had lower IL-8/IL-10 and soluble triggering receptor expressed on myeloid cells-1/IL-10 ratios. These findings indicate that individuals with SCT do not have a chronic inflammatory profile and reinforce that cytokines are involved in the maintenance of the inflammatory state in SCA.