Epigenetic Signatures of Asthma: A Comprehensive Study of DNA Methylation and Clinical Markers.

Austin J Van Asselt Jeffrey J Beck Brandon N Johnson Casey T FinnicumNoah KallsenSarah VietPatricia HuizengaLannie Ligthart Jouke- Jan Hottenga René Pool Anke H Maitland-van der Zee Susanne J H Vijverberg Eco J C N de Geus Dorret I Boomsma Erik A Ehli Jenny Van Dongen

Published in: medRxiv : the preprint server for health sciences (2024)

We identified 270 unique CpGs that were associated with PC scores generated from 35 clinical markers of asthma, either cross-sectionally or 10 years later. A strong correlation was present between effect sizes at the 2 timepoints. Most associations were identified for PC7, which captured blood eosinophil counts and immunoglobulin levels and many of these CpGs have previous associations in earlier studies of asthma and asthma-related traits. The results point to using this robust DNA methylation profile as a new, stable biomarker for asthma.

Keyphrases

dna methylation
chronic obstructive pulmonary disease
lung function
allergic rhinitis
genome wide
gene expression
cystic fibrosis
air pollution
copy number
drug induced