Surgically induced deficiency of sex hormones modulates coronary vasodilation by estradiol in hypertension.
Wender do Nascimento RouverCassiano Ricardo Souza FerreiraNathalie Tristão Banhos DelgadoRoger Lyrio Dos SantosPublished in: Journal of basic and clinical physiology and pharmacology (2020)
Our results indicated that the vasodilator effect of E2 was mediated by an indirect mechanism - via endothelium - as well as by direct action - via vascular smooth muscle - in both groups. The characterization of these mechanisms in coronary arteries might shed light on the functional basis of hormonal dysfunction symptoms in hypertension.