Hypoglycemic effects of Trichosanthes kirilowii and its protein constituent in diabetic mice: the involvement of insulin receptor pathway.

Hsin-Yi LoTsai-Chung LiTse-Yen YangChia-Cheng LiJen-Huai ChiangChien-Yun HsiangTin-Yun Ho

Published in: BMC complementary and alternative medicine (2017)

In conclusion, this study applied a bed-to-bench approach to elucidate the hypoglycemic efficacies and mechanisms of TK on clinical usage. In addition, we newly identified a hypoglycemic protein TKP from TK. Our findings might provide a reasonable explanation of TK on the treatment of diabetes in TCM.

Keyphrases

type diabetes
glycemic control
protein protein
binding protein
cardiovascular disease
amino acid
small molecule
metabolic syndrome
skeletal muscle
insulin resistance
weight loss
replacement therapy