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Hypoglycemic effects of Trichosanthes kirilowii and its protein constituent in diabetic mice: the involvement of insulin receptor pathway.

Hsin-Yi LoTsai-Chung LiTse-Yen YangChia-Cheng LiJen-Huai ChiangChien-Yun HsiangTin-Yun Ho
Published in: BMC complementary and alternative medicine (2017)
In conclusion, this study applied a bed-to-bench approach to elucidate the hypoglycemic efficacies and mechanisms of TK on clinical usage. In addition, we newly identified a hypoglycemic protein TKP from TK. Our findings might provide a reasonable explanation of TK on the treatment of diabetes in TCM.
Keyphrases
  • type diabetes
  • glycemic control
  • protein protein
  • binding protein
  • cardiovascular disease
  • amino acid
  • small molecule
  • metabolic syndrome
  • skeletal muscle
  • insulin resistance
  • weight loss
  • replacement therapy