Lack of B and T cell reactivity towards IDH1R132H in blood and tumor tissue from LGG patients.

Bas WeeninkMandy van BrakelRebecca WijersPeter A E Sillevis SmittPim J FrenchReno Debets

Published in: Journal of neuro-oncology (2019)

The absence of both humoral and cellular responses in blood and tumors of LGG patients indicates that IDH1R132H is not sufficiently immunogenic and devaluates its further therapeutic exploitation, at least in the majority of LGG patients.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
peritoneal dialysis
immune response
patient reported outcomes
low grade
high grade