Design, Synthesis, In vitro and In vivo Evaluation of New Imidazo[1,2-a]pyridine Derivatives as Cyclooxygenase-2 Inhibitors.
Nahid AhmadiMona KhoramjouyMahsa Azami MovahedSalimeh AmidiMehrdad FaiziAfshin ZarghiPublished in: Anti-cancer agents in medicinal chemistry (2024)
The majority of the compounds examined demonstrated selectivity and potency as inhibitors of COX-2. Furthermore, the analgesic effects observed of potent compounds can be attributed to the inhibition of the cyclooxygenase enzyme.