Personalized circulating tumor DNA detection to monitor immunotherapy efficacy and predict outcome in locally advanced or metastatic non-small cell lung cancer.
Lei ChengGuanghui GaoChao ZhaoHaowei WangChao YaoHanchuanzhi YuJichen YaoFeng LiLijie GuoQijie JianXiaoxia ChenXuefei LiCaicun ZhouPublished in: Cancer medicine (2023)
The tumor-informed assay was favorable for ctDNA detection, and early dynamic changes in plasma ctDNA may be a valuable biomarker for monitoring the efficacy and predicting the outcome in advanced NSCLC patients treated with first-line ICIs ± chemotherapy.
Keyphrases
- circulating tumor
- locally advanced
- circulating tumor cells
- cell free
- squamous cell carcinoma
- small cell lung cancer
- loop mediated isothermal amplification
- rectal cancer
- real time pcr
- neoadjuvant chemotherapy
- label free
- radiation therapy
- phase ii study
- clinical trial
- advanced non small cell lung cancer
- tyrosine kinase
- brain metastases